SNAP29
Description
The SNAP29 (synaptosome associated protein 29) is a protein-coding gene located on chromosome 22.
SNAP29 is a protein involved in multiple membrane trafficking steps. It is a member of the SNAP25 gene family and encodes a protein that binds a syntaxin protein and mediates synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by SNAP29 binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Multiple polyadenylation sites have been noted for this gene. SNAP29 has been shown to interact with Syntaxin 3 and EHD1.
SNAP29 is a SNARE protein that plays a crucial role in membrane fusion events within cells. It facilitates the fusion of autophagosomes with lysosomes, a process essential for cellular waste disposal. Additionally, SNAP29 contributes to ciliogenesis by regulating membrane fusion events during the formation of cilia. These functions are achieved through the formation of a SNARE complex composed of SNAP29, VAMP8, and STX17, which drives membrane fusion.
SNAP29 is also known as CEDNIK, SNAP-29.
