SLC9A1
Description
The SLC9A1 (solute carrier family 9 member A1) is a protein-coding gene located on chromosome 1.
SLC9A1 (also known as Sodium/hydrogen exchanger 1 or NHE-1) is a protein that in humans is encoded by the SLC9A1 gene. This protein is a sodium–hydrogen antiporter, a membrane-bound enzyme found in many types of cells. It plays a vital role in regulating cell volume and pH. SLC9A1 is inhibited by the drug amiloride and activated by various signals like growth factors and neurotransmitters. It interacts with several proteins, including carbonic anhydrase II, CHP, and is the target of the drug rimeporide, which is being developed to treat Duchenne muscular dystrophy.
SLC9A1 is an electroneutral sodium-hydrogen antiporter that exchanges intracellular protons (H+) for extracellular sodium ions (Na+) in a 1:1 ratio. This process is driven by the inward sodium ion gradient and protects cells from acidification caused by metabolism. SLC9A1 plays a crucial role in maintaining intracellular pH and cell volume, which are essential for cell growth, proliferation, migration, and survival. Additionally, it can transport lithium (Li+) and act as a Na+/Li+ antiporter. SLC9A1 also participates in membrane anchoring and organizing scaffolding complexes that coordinate signaling inputs.
SLC9A1 is also known as APNH, LIKNS, NHE-1, NHE1, PPP1R143.
