NUP62
Description
The NUP62 (nucleoporin 62) is a protein-coding gene located on chromosome 19.
NUP62, also known as nuclear pore glycoprotein p62, is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. It is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. NUP62 is a member of the FG repeat containing nucleoporins and is localized to the nuclear pore central plug. It associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. NUP62 is a serine/threonine rich protein of ~520 amino acids, with tetrapeptide repeats on the amino terminus and a series of alpha-helical regions with hydrophobic heptad repeats forming beta-propeller domain.
NUP62 is an essential component of the nuclear pore complex, playing a crucial role in the regulation of nucleocytoplasmic transport. Its N-terminal region is likely involved in this transport process, while the C-terminal region facilitates protein-protein interactions through coiled-coil formation. This interaction promotes NUP62‘s association with centrosomes and may contribute to its anchorage within the nuclear pore complex. NUP62 plays a significant role in the mitotic cell cycle, regulating centrosome segregation, centriole maturation, and spindle orientation. It is potentially involved in the recruitment of proteins to the centrosome after nuclear breakdown. These functions are supported by experimental evidence (PubMed:1915414, PubMed:24107630).
NUP62 is also known as IBSN, SNDI, p62.
