MME

Description

The MME (membrane metalloendopeptidase) is a protein-coding gene located on chromosome 3.

MME may stand for: Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, Enkephalinase, Neutral endopeptidase 24.11, Skin fibroblast elastase.

MME exhibits thermolysin-like specificity, primarily acting on polypeptides with up to 30 amino acids. It plays a crucial role in degrading opioid peptides like Met- and Leu-enkephalins by cleaving the Gly-Phe bond. Additionally, MME cleaves bradykinin, substance P, and neurotensin peptides. It has the capability to cleave angiotensin-1, angiotensin-2, and angiotensin 1-9. MME is involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Furthermore, it displays UV-inducible elastase activity towards skin preelastic and elastic fibers.

MME is also known as CALLA, CD10, CMT2T, NEP, SCA43, SFE.

Associated Diseases

• Congenital membranous nephropathy due to fetomaternal anti-neutral endopeptidase alloimmunization
• Spinocerebellar ataxia type 43
• Spinocerebellar ataxia 43
• Charcot-Marie-Tooth disease, axonal, type 2T