IVD : isovaleryl-CoA dehydrogenase
Description
The IVD (isovaleryl-CoA dehydrogenase) is a protein-coding gene located on chromosome 15.
The IVD gene provides instructions for making isovaleryl-CoA dehydrogenase, an enzyme essential for processing dietary proteins. Our bodies break down proteins into amino acids, which are further processed for energy, growth, and development. This enzyme resides within mitochondria, the energy factories of cells, and specifically aids in the breakdown of leucine, a particular amino acid. The enzyme catalyzes the third step in leucine breakdown, converting isovaleryl-CoA into 3-methylcrotonyl-CoA. Further reactions transform this product into molecules used for energy.
The IVD gene encodes for an enzyme, isovaleryl-CoA dehydrogenase, which plays a crucial role in the breakdown of leucine, an amino acid obtained from our diet. It catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA, a key step in leucine metabolism. Additionally, it can also oxidize other short-chain fatty acids like pentanoyl-CoA, hexenoyl-CoA, and butenoyl-CoA, though to a lesser extent.
IVD is also known as ACAD2, IVDH.
