FOXG1

Description

The FOXG1 gene, located on chromosome 14, plays a critical role in brain development. It encodes a transcription factor that regulates the expression of numerous genes essential for the formation and function of various brain structures. FOXG1 is particularly active during early brain development, and its proper function is crucial for the development of the cerebral cortex, the outermost layer of the brain responsible for higher cognitive functions. Mutations in the FOXG1 gene can lead to a range of neurodevelopmental disorders.

Associated Diseases

• FOXG1 Syndrome
• Microcephaly
• Intellectual Disability
• Seizures
• Cerebral Palsy
• Autism Spectrum Disorder

Did you know?

FOXG1 is considered a ‘master regulator‘ of brain development because it controls the expression of a vast number of genes involved in various brain processes.