DDOST
Description
The DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit) is a protein-coding gene located on chromosome 1.
DDOST is a gene that encodes a protein component of the oligosaccharyltransferase complex, which is responsible for attaching sugar molecules (glycans) to proteins. This process, called glycosylation, is essential for proper protein folding and function. The protein encoded by DDOST is involved in transferring high-mannose oligosaccharides to asparagine residues on newly made proteins within the endoplasmic reticulum, a cellular compartment. This protein is also implicated in the processing of advanced glycation endproducts (AGEs), which are harmful byproducts of sugar reactions that contribute to aging and diabetes.
DDOST is a subunit of the oligosaccharyl transferase (OST) complex. The OST complex catalyzes the initial transfer of a specific glycan (Glc(3)Man(9)GlcNAc(2)) from dolichol-pyrophosphate, a lipid carrier, to an asparagine residue within a specific sequence motif (Asn-X-Ser/Thr) in newly synthesized polypeptide chains. This process is the first step in protein N-glycosylation. N-glycosylation occurs during protein synthesis, and the OST complex interacts with the Sec61 complex, a channel-forming complex involved in protein translocation across the endoplasmic reticulum. All subunits of the OST complex are required for optimal enzyme activity. DDOST plays a role in the assembly of both SST3A- and SS3B-containing OST complexes.
DDOST is also known as AGER1, CDG1R, GATD6, OKSWcl45, OST, OST48, WBP1.
