CIT
Description
The CIT gene encodes for citrate synthase, a crucial enzyme in the citric acid cycle (Krebs cycle). This cycle is the central hub of cellular energy production, converting nutrients into ATP, the cell's primary energy currency. Citrate synthase catalyzes the first step of the citric acid cycle, the condensation of acetyl-CoA and oxaloacetate to form citrate. This reaction is essential for the efficient functioning of the mitochondria, the cell's powerhouses, and overall cellular metabolism.
Associated Diseases
- Citrate synthase deficiency: A rare genetic disorder characterized by a deficiency in the activity of citrate synthase, leading to various metabolic complications.
- Mitochondrial diseases: Mutations in the CIT gene can contribute to the development of mitochondrial diseases, characterized by dysfunction in the mitochondria.
- Cancer: Altered expression of CIT has been implicated in various types of cancer, including prostate and breast cancer.
Did you know?
Citrate synthase is a highly conserved enzyme, meaning its structure and function are similar across different organisms, highlighting its importance in basic cellular processes.
