CHKB
Description
The CHKB gene, encodes for the Chk1 protein, a critical checkpoint kinase involved in the DNA damage response (DDR) pathway. This pathway ensures the integrity of our genome by halting cell cycle progression when DNA damage is detected, allowing for repair mechanisms to operate. Chk1 acts as a cellular guardian, preventing the propagation of damaged DNA and potentially cancerous cells. Its role in regulating cell cycle checkpoints makes it a crucial player in maintaining genomic stability and preventing tumorigenesis.
Associated Diseases
- Cancer (e.g., breast cancer, ovarian cancer, colorectal cancer)
- Fanconi anemia
- Ataxia telangiectasia
- Bloom syndrome
Did you know?
Mutations in the CHKB gene have been linked to increased cancer risk and sensitivity to DNA damaging agents.
