AMPD2

Description

The AMPD2 (adenosine monophosphate deaminase 2) is a protein-coding gene located on chromosome 1.

AMP deaminase 2 is an enzyme encoded by the AMPD2 gene in humans. High levels of AMPD2 expression in undifferentiated pleomorphic sarcoma (UPS) are associated with poor patient outcomes and a proliferative tumor phenotype.

AMP deaminase plays a crucial role in energy metabolism by catalyzing the deamination of AMP to IMP, a key step in the purine nucleotide cycle.

AMPD2 is also known as AMPD, PCH9, SPG63.

Associated Diseases

• Autosomal recessive spastic paraplegia type 63
• Spastic paraplegia 63, autosomal recessive
• Pontocerebellar hypoplasia, type 9