ACADM : acyl-CoA dehydrogenase medium chain

The ACADM Gene: Unlocking the Power of Fatty Acid Metabolism


The ACADM gene plays a crucial role in our body's energy production by providing instructions for creating an essential enzyme called medium-chain acyl-CoA dehydrogenase (MCAD). Found within the mitochondria, the energy powerhouses of cells, MCAD is fundamental for fatty acid oxidation, the complex process that converts fats into usable energy.

Associated Diseases:

Mutations in the ACADM gene can cause a rare genetic disorder known as medium-chain acyl-CoA dehydrogenase deficiency (MCADD). This condition hinders the body's ability to break down medium-chain fatty acids, leading to a buildup of toxic metabolites that can damage organs and tissues. Symptoms typically manifest during infancy or early childhood and can include:

  • Vomiting
  • Seizures
  • Respiratory distress
  • Hypoglycemia (low blood sugar)

Did you Know ?

According to estimates, MCADD affects approximately 1 in 15,000 newborns in the United States. Early detection through newborn screening programs is critical for managing the condition and preventing severe complications.

Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.