GDF10
Description
The GDF10 (growth differentiation factor 10) is a protein-coding gene located on chromosome 10.
GDF10, also known as BMP-3B, is a protein produced by the GDF10 gene. It belongs to a large family of proteins called the transforming growth factor beta superfamily, and it is closely related to BMP3. GDF10 is involved in head development and may have other roles in bone formation. GDF10 and BMP3 form a separate subgroup within the TGF-beta superfamily. In mice, GDF10 is found in many tissues including the brain, inner ear, uterus, prostate, nervous system, blood vessels, and fat tissue. It is also present in bone of both young and adult mice. In humans, GDF10 is found in the developing inner ear and lungs, and in the adult testis, retina, pineal gland, and other brain tissues.
GDF10 is a growth factor involved in both bone formation (osteogenesis) and fat cell development (adipogenesis). It acts as a brake on bone-building cell (osteoblast) differentiation by using the SMAD2/3 signaling pathway. It also slows down fat cell development.
GDF10 is also known as BIP, BMP-3b, BMP3B.
