GBX2
Description
The GBX2 (gastrulation brain homeobox 2) is a protein-coding gene located on chromosome 2.
GBX2, short for Gastrulation Brain Homeobox 2, is a transcription factor essential for the proper organization of the midbrain and hindbrain during embryonic development. It controls the formation of rhombomeres 1 through 3 in the hindbrain, which are segments that contribute to various brain structures. GBX2's expression levels are crucial for proper hindbrain patterning. It also influences the expression of other genes, like FGF8, during development. Abnormalities in GBX2 expression have been linked to conditions like Colon Small Cell Carcinoma and Optiz-Gbbb Syndrome, which affects the midline of the body.
GBX2 is also known as -.
