GBP4

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Description

The GBP4 (guanylate binding protein 4) is a protein-coding gene located on chromosome 1.

GBP4 is an interferon-inducible GTPase that plays a crucial role in the innate immune system, defending against various bacterial, viral, and protozoan infections. GBP4 acts as a negative regulator of the antiviral response by suppressing the activation of the IRF7 transcription factor.

GBP4 is also known as Mpa2.

Associated Diseases

• cancer
• recurrent Neisseria infections due to factor D deficiency
• immunodeficiency 28
• isolated asymptomatic elevation of creatine phosphokinase
• varicella, severe recurrent
• candidiasis, familial, 4
• plasma fibronectin deficiency
• type II complement component 8 deficiency
• mannose-binding lectin deficiency
• immunodeficiency due to ficolin3 deficiency
• pentosuria
• myopathy due to calsequestrin and SERCA1 protein overload