GATAD2B

Description

The GATAD2B (GATA zinc finger domain containing 2B) is a protein-coding gene located on chromosome 1.

Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.

== Interactions == GATAD2B has been shown to interact with Methyl-CpG-binding domain protein 2, MBD3, RBBP7 and RBBP4.

Transcriptional repressor (PubMed:12183469, PubMed:16415179). Plays a role in chromatin remodeling as a component of the histone deacetylase NuRD complex (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Requires the presence of GATAD2A for efficient repression (PubMed:16415179). Targets MBD3 to specific locations in the nucleus (PubMed:11756549). May be involved in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}

GATAD2B is also known as GANDS, MRD18, P66beta, p68.

Associated Diseases

• Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome
• Mental retardation, autosomal dominant 18