GAS5
GAS5: The Non-Coding RNA That Fights Inflammation and Disease
Description
GAS5 (Growth Arrest-Specific 5) is a long non-coding RNA (lncRNA) that plays a crucial role in regulating gene expression. It is highly conserved across species and has been linked to various biological processes, including cell growth, apoptosis, and inflammation. GAS5 is known for its tumor-suppressive properties and its ability to protect against neurodegenerative diseases.
Associated Diseases
GAS5 has been implicated in the pathogenesis of several diseases, including:
- Cancer: GAS5 acts as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. Reduced GAS5 expression has been observed in various cancer types, including lung cancer, breast cancer, and colon cancer.
- Neurodegenerative diseases: GAS5 has neuroprotective effects and has been linked to the protection against diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
- Cardiovascular diseases: GAS5 plays a role in regulating inflammation and oxidative stress in the heart. Low GAS5 levels have been associated with an increased risk of heart failure and atherosclerosis.
- Metabolic diseases: GAS5 has been implicated in the regulation of glucose and lipid metabolism. Dysregulation of GAS5 has been linked to insulin resistance and type 2 diabetes.
Did you Know ?
Approximately 50% of patients with cancer have reduced GAS5 expression. This suggests that GAS5 may play a significant role in the development and progression of cancer.
