GAP43

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Unlocking the Mysteries of GAP43: A Neural Gem

Description

Growth-associated protein 43 (GAP43) is a protein expressed in the nervous system, primarily in neurons. It is highly expressed during development and plays a crucial role in neural plasticity, the brain's ability to adapt and change in response to experiences. GAP43 is localized to the growth cones of neurons, which are dynamic structures that guide axons as they extend and form connections with other neurons.

Associated Diseases

Alzheimer's Disease: GAP43 levels are decreased in patients with Alzheimer's disease, suggesting its involvement in the cognitive decline and memory loss associated with the condition.

Parkinson's Disease: Reduced GAP43 expression has also been observed in Parkinson's disease, which affects motor function and coordination.

Did you Know ?

• In animals, overexpression of GAP43 enhances learning and memory capabilities, demonstrating its importance for cognitive function.