GALNT6
Description
The GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6) is a protein-coding gene located on chromosome 12.
GALNT6 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. These enzymes initiate mucin-type O-linked glycosylation in the Golgi apparatus by transferring GalNAc to serine and threonine residues on proteins. GALNT6 has a transmembrane domain, a stem region, a catalytic domain with a GT1 motif and Gal/GalNAc transferase motif, and a ricin/lectin-like domain. It shows specificity for certain substrates and is expressed in various tissues. GALNT6 can glycosylate fibronectin peptide in vitro and is expressed in fibroblasts, suggesting a role in oncofetal fibronectin synthesis.
GALNT6 catalyzes the initial step in O-linked glycosylation, attaching an N-acetyl-D-galactosamine (GalNAc) residue to serine or threonine residues on proteins. This process is essential for building complex carbohydrate structures on proteins. GALNT6 has been shown to glycosylate various proteins, including MUC1A, MUC2, EA2, fibronectin, and FGF23. The enzyme might also play a role in the synthesis of oncofetal fibronectin, a protein associated with cancer.
GALNT6 is also known as GALNAC-T6, GalNAcT6.
