GAL3ST3
Description
The GAL3ST3 (galactose-3-O-sulfotransferase 3) is a protein-coding gene located on chromosome 11.
The GAL3ST3 gene encodes a member of the galactose-3-O-sulfotransferase protein family. The encoded enzyme, galactose-3-O-sulfotransferase 3, catalyzes the transfer of a sulfate group to the 3' position of galactose in N-acetyllactosamine within both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene is distinct from the GAL3ST2 gene on chromosome 2, which encodes a related enzyme with different tissue distribution and substrate specificities. This gene has also been referred to as GAL3ST2.
GAL3ST3 transfers a sulfate group to the 3' position of non-reducing beta-galactosyl residues within N-glycans and core2-branched O-glycans. Its activity is strongest towards Gal-beta-1,4-GlcNAc and Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc, but weaker towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.
GAL3ST3 is also known as GAL3ST-3, GAL3ST2.
