GADD45G
Description
The GADD45G (growth arrest and DNA damage inducible gamma) is a protein-coding gene located on chromosome 9.
GADD45G, also known as CR6, DDIT2, GRP17, OIG37, and GADD45gamma, is a protein encoded by the GADD45G gene on chromosome 9. It is involved in several processes including sexual development, human-specific brain development, tumor suppression, and the cellular stress response. GADD45G interacts with proteins involved in DNA repair, cell cycle control, apoptosis, and senescence. Low expression of GADD45G is linked to various types of cancer. GADD45G was first cloned in 1993 and identified as an immediate early response gene in T lymphocytes. Its tumor suppressor role was discovered in 1999. It was also named OIG37 due to its regulation by Oncostatin M, which inhibits growth, and Gadd-related protein 17 due to its homology with Gadd45.
GADD45G plays a crucial role in regulating cell growth and programmed cell death (apoptosis). It activates the stress-responsive MTK1/MEKK4 MAPKKK pathway, which is involved in cellular signaling.
GADD45G is also known as CR6, DDIT2, GADD45gamma, GRP17.
