GABRR2

Description

The GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2) is a protein-coding gene located on chromosome 6.

Gamma-aminobutyric acid receptor subunit rho-2 is a protein encoded by the GABRR2 gene in humans. GABA is the main inhibitory neurotransmitter in the mammalian brain, acting on GABA receptors, which are ligand-gated chloride channels. GABRR2 belongs to the rho subunit family.

GABA, the primary inhibitory neurotransmitter in the vertebrate brain, regulates neuronal activity by binding to GABA/benzodiazepine receptors, opening chloride channels. The Rho-2 GABA receptor may contribute to retinal neurotransmission.

GABRR2 is also known as -.

Associated Diseases

• thyroid gland adenocarcinoma
• esophageal cancer
• 46,XY complete gonadal dysgenesis
• 8p23.1 microdeletion syndrome
• isolated congenital hypogonadotropic hypogonadism
• 46,XY partial gonadal dysgenesis
• 46,XX ovotesticular disorder of sex development
• spermatogenic failure, X-linked, 2
• alcohol dependence
• bipolar disorder
• Rett syndrome
• migraine disorder