GABRA5
Description
The GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5) is a protein-coding gene located on chromosome 15.
GABRA5, also known as GABA(A) receptor subunit alpha-5, is a protein that is encoded by the GABRA5 gene in humans. GABA is the primary inhibitory neurotransmitter in the mammalian brain, acting on GABA(A) receptors, which are ligand-gated chloride channels. GABA(A) receptors are modulated by agents like benzodiazepines that bind to the receptor. At least 16 distinct subunits of GABA(A) receptors have been identified. GABRA5 is one of these subunits, and transcript variants using three different alternative non-coding first exons have been described. Recent research has focused on ligands selective for GABA(A) receptors containing the α5 subunit, which have proven useful in investigating side effects of benzodiazepine and nonbenzodiazepine drugs, particularly effects on learning and memory, such as anterograde amnesia. Inverse agonists at this subunit have nootropic effects and may be helpful in treating cognitive disorders like Alzheimer's disease.
GABRA5 is a subunit of the GABA receptor, a major inhibitory neurotransmitter in the brain. It plays a role in GABA receptor assembly and immobilization at the synapse, potentially contributing to the regulation of GABAergic signaling.
GABRA5 is also known as DEE79, EIEE79.
