FZD7

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Title: FZD7: A Key Player in Development and Disease

Description:

FZD7, short for Frizzled class 7, is a protein belonging to the seven-transmembrane domain (TM7) family of G protein-coupled receptors. It is a crucial regulator of the Wnt signaling pathway, a vital process involved in various aspects of development and disease.

Associated Diseases:

Dysregulation of FZD7 has been implicated in several diseases, including:

• Osteoporosis: FZD7 plays a role in bone formation and maintenance. Mutations in FZD7 have been linked to decreased bone density and increased fracture risk.
• Alzheimer's Disease: FZD7 is expressed in the brain and may be involved in neuronal development and function. Alterations in FZD7 signaling have been associated with Alzheimer's disease pathogenesis.
• Cancer: FZD7 has been found to be both upregulated and downregulated in different types of cancer. Its deregulation may contribute to tumor growth, metastasis, and drug resistance.

Did you Know ?

In individuals with osteoporosis caused by FZD7 mutations, bone mineral density can be reduced by up to 50% compared to healthy individuals.