FXYD6
Description
The FXYD6 (FXYD domain containing ion transport regulator 6) is a protein-coding gene located on chromosome 11.
FXYD6, also known as FXYD domain-containing ion transport regulator 6, is a gene located on chromosome 11. It encodes a protein of 95 amino acids found in all human tissues except blood. FXYD6 belongs to the FXYD family of ion transport regulators. Recent research suggests mutations in FXYD6 or nearby sequences may increase the risk of schizophrenia, a condition known to have a strong genetic component.
FXYD6, also known as Phosphohippolin, plays a crucial role in regulating the activity of the sodium/potassium-transporting ATPase (NKA). This protein, which is involved in the exchange of sodium and potassium ions across cell membranes, influences the NKA's affinity for sodium ions, making it less likely to bind to sodium inside the cell. However, it doesn't affect the NKA's ability to bind potassium outside the cell. FXYD6 also potentially contributes to the NKA's proper positioning within the cell membrane. As a regulatory subunit of the NKA complex, FXYD6 specifically fine-tunes the NKA's function in different tissues and cell types by altering its affinity for sodium, potassium, and ATP.
FXYD6 is also known as -.
