FSTL3

Description

The FSTL3 (follistatin like 3) is a protein-coding gene located on chromosome 19.

Follistatin-related protein 3 is a protein encoded by the FSTL3 gene in humans. It is a secreted glycoprotein belonging to the follistatin-module-protein family and may play a role in leukemogenesis.

FSTL3 isoform 1, secreted, binds to and antagonizes members of the TGF-beta family, including activin, BMP2, and MSTN. It inhibits cellular signaling induced by activin A, activin B, BMP2, and MSDT, with a stronger effect on activin A than on activin B. FSTL3 plays a role in bone formation by inhibiting osteoclast differentiation. It is also involved in hematopoiesis, promoting the differentiation of hematopoietic progenitor cells and increasing their adhesion to fibronectin, contributing to the attachment of hematopoietic precursor cells to the bone marrow stroma. FSTL3 isoform 2, nuclear, is likely involved in transcriptional regulation through interaction with MLLT10.

FSTL3 is also known as FLRG, FSRP.

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