FPR3
FPR3: A Key Receptor in Immune Response and Disease
Description
Formyl peptide receptor 3 (FPR3), also known as lipoxin A4 receptor, is a G protein-coupled receptor (GPCR) that plays a crucial role in the immune system. It is primarily expressed in neutrophils, monocytes, macrophages, and dendritic cells. FPR3 binds to various ligands, including formylated peptides, annexin A1, and lipoxin A4, which are involved in inflammation and immune responses.
Associated Diseases
FPR3 dysregulation has been implicated in several inflammatory diseases and conditions:
- Atopic dermatitis: Elevated FPR3 expression in skin lesions contributes to inflammation and pruritus.
- Asthma: FPR3 activation by cigarette smoke and other inflammatory stimuli promotes airway inflammation and hyperresponsiveness.
- Rheumatoid arthritis: FPR3 expression is increased in synovial tissue and contributes to joint inflammation and destruction.
- Inflammatory bowel disease: FPR3 activation by gut microbiota promotes intestinal inflammation and tissue damage.
- Sepsis: FPR3 deficiency impairs neutrophil recruitment and bacterial clearance, contributing to systemic inflammation and organ failure.
Did you Know ?
According to a study published in the journal "Nature Immunology", FPR3 knockout mice exhibit a 50% reduction in neutrophil migration to sites of inflammation, highlighting the receptor's critical role in immune cell recruitment.
