FPGS

Description

The FPGS (folylpolyglutamate synthase) is a protein-coding gene located on chromosome 9.

FPGS may refer to Folylpolyglutamate synthase, mitochondrial.

FPGS catalyzes the conversion of folates to polyglutamate derivatives, which enhances the concentration of folate compounds within the cell and their retention. This process is crucial for various folate-dependent enzymes involved in one-carbon transfer reactions, essential for the synthesis of purines, pyrimidines, and amino acids. Notably, unsubstituted reduced folates are preferred substrates for this enzyme. Additionally, FPGS metabolizes methotrexate (MTX) to polyglutamates. This information is supported by multiple studies.

FPGS is also known as -.

Associated Diseases

• hyper-IgM syndrome type 3
• classic Hodgkin lymphoma
• immune deficiency, familial variable
• hyper-IgM syndrome type 2
• hyper-IgM syndrome type 5
• immunodeficiency, common variable, 14
• BENTA disease
• cancer