FOXO4

Description

The FOXO4 (forkhead box O4) is a protein-coding gene located on chromosome X.

FOXO4 is a member of the forkhead family of transcription factors, characterized by a winged helix domain used for DNA binding. It regulates many cellular pathways including oxidative stress signaling, longevity, insulin signaling, cell cycle progression, and apoptosis. Its activity is modified by phosphorylation, ubiquitination, and acetylation, which alter its DNA binding affinity. FOXO4 is regulated by PI3K and AKT, which prevent it from translocating to the nucleus and inhibiting downstream FOXO targets. FOXO4 has been linked to longevity, as it is involved in the insulin-like growth factor (IGF) signaling pathway. In the absence of insulin, FOXO4 can translocate to the nucleus and activate pathways associated with longevity. FOXO4 can also bind with p53 protein to induce cellular senescence.

Transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. FOXO4 plays a role in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

FOXO4 is also known as AFX, AFX1, MLLT7.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing