FOXO3B

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Description

The FOXO3B (forkhead box O3B) is a protein-coding gene located on chromosome 17.

FOXO3B is a gene that codes for a protein called Forkhead box protein O3B. This protein acts as a transcription factor, which means it can bind to DNA and regulate the expression of other genes. FOXO3B plays a crucial role in various cellular processes, including cell growth, differentiation, metabolism, and stress resistance. It is also implicated in aging and age-related diseases, such as cancer and Alzheimer's disease. Research suggests that FOXO3B may influence lifespan and healthspan.

Transcription factor involved in regulating various cellular processes, including cell growth, differentiation, metabolism, and stress resistance.

FOXO3B is also known as FKHRL1P1, ZNF286C.

Associated Diseases

• hemoglobin D disease
• 46,XY complete gonadal dysgenesis
• male infertility with teratozoospermia due to single gene mutation
• 46,XX testicular disorder of sex development
• common variable immunodeficiency
• T-B+ severe combined immunodeficiency due to JAK3 deficiency
• autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
• hemoglobin E disease
• dehydrated hereditary stomatocytosis
• combined immunodeficiency due to ZAP70 deficiency
• autoimmune lymphoproliferative syndrome type 2B
• immunodeficiency 72 with autoinflammation
• 46,XX ovotesticular disorder of sex development
• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
• beta-thalassemia-X-linked thrombocytopenia syndrome
• familial hyperprolactinemia
• X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
• hyper-IgM syndrome type 5
• primary familial polycythemia due to EPO receptor mutation