FOXJ1
Description
The FOXJ1 (forkhead box J1) is a protein-coding gene located on chromosome 17.
FOXJ1 is a protein encoded by the FOXJ1 gene in humans. It belongs to the Forkhead/winged helix (FOX) family of transcription factors and plays a crucial role in ciliogenesis. FOXJ1 is expressed in ciliated cells of the lung, choroid plexus, reproductive tract, embryonic kidney, and pre-somite embryo stage. The FOXJ1 gene is located on chromosome 17, specifically on the long arm, region 2, band 5, sub-band 1. FOXJ1 contains a conserved DNA binding domain spanning 100 amino acids. The protein is essential for primary ciliogenesis, and its expression marks cells destined to become motile ciliated cells. Similar genes in zebrafish and mouse regulate the transcription of genes involved in motile cilia production, and the mouse ortholog also influences left-right asymmetry.
FOXJ1 is a transcription factor essential for the formation of motile cilia. It activates the transcription of genes involved in motile cilia assembly, such as CFAP157. FOXJ1 binds to specific DNA sequences, 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3', and regulates the expression of various ciliary proteins during brain and lung development.
FOXJ1 is also known as CILD43, FKHL13, HFH-4, HFH4.
