FOLH1B
Description
The FOLH1B (folate hydrolase 1B (pseudogene)) is a pseudo gene located on chromosome 11.
FOLH1B is a gene that encodes the protein folylpolyglutamate synthetase 1 beta. This protein is involved in the folate metabolism pathway, where it catalyzes the addition of glutamate residues to tetrahydrofolate (THF) to form polyglutamate derivatives. These derivatives are essential for the proper function of several folate-dependent enzymes involved in nucleotide biosynthesis, DNA synthesis, and repair.
FOLH1B, also known as Folylpolyglutamate Synthetase 1 Beta, is an enzyme that plays a crucial role in the folate metabolism pathway. It catalyzes the addition of glutamate residues to tetrahydrofolate (THF), forming polyglutamate derivatives. These derivatives are essential for the proper function of several folate-dependent enzymes involved in nucleotide biosynthesis, DNA synthesis, and repair. FOLH1B is primarily expressed in the liver and kidney, but it can also be found in other tissues. Its activity is regulated by various factors, including the availability of folate, the levels of folate-dependent enzymes, and the cellular energy status.
FOLH1B is also known as FOLH2, FOLHP, PSM, PSMA-LIKE, PSMAL.
