FNBP1L
Description
The FNBP1L (formin binding protein 1 like) is a protein-coding gene located on chromosome 1.
FNBP1L, or Formin-binding protein 1-like, is a protein encoded by the FNBP1L gene in humans. It binds to both CDC42 and N-WASP, promoting CDC42-induced actin polymerization by activating the N-WASP-WIP complex. This protein links cell surface signals to the actin cytoskeleton. Different isoforms arise from alternative splicing. Certain FNBP1L polymorphisms, particularly the SNP rs236330, have been associated with variations in intelligence levels in both adults and children.
FNBP1L plays a crucial role in coordinating membrane tubulation with actin cytoskeleton reorganization during endocytosis. It interacts with lipids like phosphatidylinositol 4,5-bisphosphate and phosphatidylserine, promoting membrane invagination and tubule formation. Additionally, FNBP1L activates the WASL/N-WASP-WASPIP/WIP complex, the primary form of WASL/N-WASP in cells, leading to CDC42-induced actin polymerization. This polymerization is believed to promote the fission of membrane tubules, forming endocytic vesicles. Notably, FNBP1L is essential for the autophagy of intracellular bacterial pathogens.
FNBP1L is also known as C1orf39, TOCA1.
