FNBP1
Description
The FNBP1 (formin binding protein 1) is a protein-coding gene located on chromosome 9.
Formin-binding protein 1 (FNBP1) is a protein encoded by the FNBP1 gene in humans. It belongs to the formin-binding-protein family and contains multiple domains: an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain, a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. FNBP1 interacts with sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin, although an interaction with formin has not been observed in humans.
FNBP1 is involved in the regulation of actin cytoskeleton by linking RND2 signaling to actin cytoskeleton reorganization. It plays a critical role in the late stages of clathrin-mediated endocytosis by coordinating membrane tubulation with actin cytoskeleton reorganization. FNBP1 binds to specific lipids, including phosphatidylinositol 4,5-bisphosphate and phosphatidylserine, promoting membrane invagination and tubule formation. FNBP1 enhances actin polymerization by recruiting WASL/N-WASP, which activates the Arp2/3 complex. This actin polymerization contributes to the fission of membrane tubules into endocytic vesicles. FNBP1 may also be involved in the lysosomal retention of FASLG/FASL.
FNBP1 is also known as FBP17.
