FMO4
Description
The FMO4 (flavin containing dimethylaniline monoxygenase 4) is a protein-coding gene located on chromosome 1.
The FMO4 gene encodes an enzyme called dimethylaniline monooxygenase [N-oxide-forming] 4, which plays a crucial role in the body's detoxification process. It is responsible for breaking down trimethylamine (TMA), a compound produced by the digestion of certain foods, particularly fish. Variations in the FMO3 gene can lead to reduced TMA breakdown, resulting in a condition called trimethylaminuria, characterized by a strong fish odor. FMO4, along with FMO1 and FMO2, are members of a family of enzymes known as flavin-containing monooxygenases (FMOs). These enzymes utilize NADPH and flavin adenine dinucleotide (FAD) as cofactors to catalyze oxidation reactions, specifically targeting soft nucleophilic heteroatom centers. Notably, FMO4's expression has been observed to decrease in precancerous cervical cells, suggesting a potential role in tumorigenesis and a possible marker for cervical cancer progression.
FMO4 plays a role in breaking down foreign substances in the body, such as drugs and pesticides, through oxidative metabolism.
FMO4 is also known as FMO2.
