FLRT1
Description
The FLRT1 (fibronectin leucine rich transmembrane protein 1) is a protein-coding gene located on chromosome 11.
Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in the kidney and brain.
FLRT1 is involved in fibroblast growth factor (FGF) signaling pathways that activate MAP kinases. It contributes to neurite outgrowth by activating MAP kinases through FGFR1. This protein promotes an increase in both the number and length of neurites. Additionally, FLRT1 might participate in cell-cell adhesion and cell guidance through its interactions with ADGRL1/LPHN1 and ADGRL3.
FLRT1 is also known as SPG68.
