FLII
Description
The FLII (FLII actin remodeling protein) is a protein-coding gene located on chromosome 17.
The human FLII gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. It shares similarities with a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The FLII gene is located within the Smith-Magenis syndrome region on chromosome 17. FLII interacts with LRRFIP1 and TRAF interacting protein.
FLII may act as a coactivator in transcriptional activation triggered by hormone-activated nuclear receptors (NR), collaborating with NCOA2 and CARM1. It participates in estrogen hormone signaling and is implicated in early embryonic development. FLII might regulate cytoskeletal rearrangements during cytokinesis and cell migration by inhibiting Rac1-dependent paxillin phosphorylation.
FLII is also known as CMD2J, FLI, FLIL, Fli1.
