FKBP4

Description

The FKBP4 (FKBP prolyl isomerase 4) is a protein-coding gene located on chromosome 12.

FKBP4, also known as FK506-binding protein 4, is a protein encoded by the FKBP4 gene in humans. It belongs to the immunophilin protein family, which plays a role in immunoregulation and fundamental cellular processes involving protein folding and trafficking. FKBP4 is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It shares high structural and functional similarity to FKBP1A, but unlike FKBP1A, it lacks immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and is crucial for immunoregulatory gene expression in B and T lymphocytes. It is known to associate with phytanoyl-CoA alpha-hydroxylase and can also interact with two heat shock proteins (hsp90 and hsp70), potentially playing a role in the intracellular trafficking of hetero-oligomeric forms of steroid hormone receptors. FKBP4 exhibits a strong correlation with adeno-associated virus type 2 vectors (AAV), leading to a significant increase in AAV-mediated transgene expression in human cell lines. This suggests that FKBP4 may have significant implications for the optimal use of AAV vectors in human gene therapy. FKBP4 contains TPR repeats and possesses a PPlase domain.

FKBP4, also known as FK506-binding protein 4, is an immunophilin protein that exhibits peptidyl-prolyl cis-trans isomerase (PPIase) and co-chaperone activities. It forms part of steroid receptor heterocomplexes by interacting with heat-shock protein 90 (HSP90). FKBP4 potentially contributes to the intracellular trafficking of steroid hormone receptors between the cytoplasm and nuclear compartments. Its isomerase activity regulates neuronal growth cones through modulation of TRPC1 channel opening. FKBP4 acts as a regulator of microtubule dynamics by hindering the ability of MAPT/TAU to promote microtubule assembly. It may offer protection against oxidative stress within mitochondria.

FKBP4 is also known as FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52.

Associated Diseases

WES Whole Exome Sequencing