FIP1L1 : factor interacting with PAPOLA and CPSF1
Description
The FIP1L1 (factor interacting with PAPOLA and CPSF1) is a protein-coding gene located on chromosome 4.
The FIP1L1 gene provides instructions for making part of a protein complex named cleavage and polyadenylation specificity factor (CPSF). This complex of proteins plays an important role in processing molecules called messenger RNAs (mRNAs), which serve as the genetic blueprints for making proteins. The CPSF protein complex helps add a string of the RNA building block adenine to the mRNA, creating a polyadenine tail or poly(A) tail. The poly(A) tail is important for stability of the mRNA and for protein production from the blueprint.
The FIP1L1 gene produces a protein that is part of the cleavage and polyadenylation specificity factor (CPSF) complex. This complex is crucial for the processing of messenger RNA (mRNA), which carries genetic instructions for making proteins. FIP1L1 helps to recognize the AAUAAA signal sequence on pre-mRNA, which is a signal for where to add a poly(A) tail. It also interacts with poly(A) polymerase and other factors to ensure the correct cleavage and addition of the poly(A) tail. This tail is essential for the stability of mRNA and for proper protein production. FIP1L1 also binds to U-rich RNA sequence elements near the poly(A) site and may help to attach poly(A) polymerase to the CPSF complex.
FIP1L1 is also known as FIP1, Rhe, hFip1.
