FIGN
Description
The FIGN (fidgetin, microtubule severing factor) is a protein-coding gene located on chromosome 2.
FIGN is an ATP-dependent microtubule severing protein that cuts microtubules along their length and breaks them down, particularly at the minus-end. This action can limit microtubule growth from and attachment to centrosomes. By severing microtubules, FIGN facilitates rapid reorganization of the cell's microtubule network and allows microtubules to detach from the centrosome after they form. When microtubules detach from the poles of the mitotic spindle, FIGN helps break down the microtubule end closest to the spindle pole, driving the movement of microtubules towards the poles and the movement of chromosomes towards the poles.
FIGN is also known as -.
