FIGF
Introduction
Fibrosis is a complex biological process characterized by the excessive deposition of fibrous connective tissue, leading to the thickening and scarring of organs. It plays a significant role in various chronic diseases, impairing organ function and eventually leading to organ failure.
Description
Fibrosis occurs when normal tissue is replaced by a dense network of collagen fibers, which are produced by specialized cells called myofibroblasts. This excessive collagen deposition can result in the hardening and stiffening of tissues, leading to impaired function. Fibrosis can affect various organs, including the liver, lungs, kidneys, heart, and skin.
Associated Diseases
Fibrosis is associated with a wide range of chronic diseases, including:
- Liver fibrosis: Cirrhosis, hepatitis, alcohol-related liver disease
- Pulmonary fibrosis: Idiopathic pulmonary fibrosis, sarcoidosis
- Renal fibrosis: Chronic kidney disease, diabetes
- Cardiac fibrosis: Myocardial infarction, heart failure
- Skin fibrosis: Scleroderma, keloids
Did you Know ?
According to the World Health Organization, liver cirrhosis, a result of fibrosis, is the 11th leading cause of death worldwide, highlighting the significant impact of fibrosis on global health.
