FHL2
Description
The FHL2 (four and a half LIM domains 2) is a protein-coding gene located on chromosome 2.
FHL2, also known as Four and a half LIM domains protein 2, is a protein encoded by the FHL2 gene in humans. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain. FHL2 is thought to play a role in the assembly of extracellular membranes and may act as a link between presenilin-2 and an intracellular signaling pathway. FHL2 belongs to the Four-and-a-half LIM (FHL)-only protein subfamily, a member of the LIM-only protein family. Proteins within this subfamily share a high degree of similarity in their amino acid sequence and are defined by the presence of four and a half cysteine-rich LIM homeodomains with the half-domain located at the N-terminus. The LIM domain does not directly interact with DNA; instead, evidence suggests that FHL2 plays a functional role in supporting protein-protein interactions of LIM-containing proteins and its binding partners. Five members have been categorized into the FHL subfamily: FHL1, FHL2, FHL3, FHL4, and activator of CREM in testis (ACT) in humans.
FHL2 acts as a molecular intermediary, connecting various signaling pathways to transcriptional regulation. It inhibits the transcriptional repressor E4F1, potentially influencing cell growth. FHL2 also suppresses the transcriptional activity of FOXO1 and its role in apoptosis by promoting the interaction of FOXO1 with SIRT1, leading to FOXO1 deacetylation. Additionally, FHL2 negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.
FHL2 is also known as AAG11, DRAL, FHL-2, SLIM-3, SLIM3.
