FGFBP1
Description
The FGFBP1 (fibroblast growth factor binding protein 1) is a protein-coding gene located on chromosome 4.
Fibroblast growth factor-binding protein 1 (FGFBP1) is a protein encoded by the FGFBP1 gene in humans. It binds reversibly to both acidic FGF1 and basic FGF2 fibroblast growth factors. FGFBP1 also binds to perlecan (HSPG2). It has been shown to interact with perlecan.
FGFBP1 acts as a carrier protein, releasing fibroblast-binding factors (FGFs) from extracellular matrix storage, thereby enhancing their mitogenic activity. It specifically promotes FGF2 signaling during tissue repair, angiogenesis, and tumor growth.
FGFBP1 is also known as FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17.
