FGF14

Description

The FGF14 (fibroblast growth factor 14) is a protein-coding gene located on chromosome 13.

FGF14 is a protein involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It is mainly expressed in the central nervous system and is associated with neurodegenerative diseases such as spinocerebellar ataxia (SCA27) and Alzheimer's disease. FGF14 deficiency can impair the maturation of cells in the hippocampus, which may be related to the development of schizophrenia. Mutations in the FGF14 gene have been linked to autosomal dominant cerebellar ataxia. Research is ongoing to explore the potential of FGF14 as a therapy for Alzheimer's disease and other neurodegenerative diseases.

FGF14 is also known as FGF-14, FHF-4, FHF4, NYS4, SCA27, SCA27A, SCA27B.

Associated Diseases

• Spinocerebellar ataxia 27B, late-onset
• Nystagmus 4, congenital, autosomal dominant
• Spinocerebellar ataxia type 27