FGD1 : FYVE, RhoGEF and PH domain containing 1
Description
The FGD1 (FYVE, RhoGEF and PH domain containing 1) is a protein-coding gene located on chromosome X.
The FGD1 gene provides instructions for making a protein that functions as a guanine nucleotide exchange factor (GEF). GEFs activate proteins called GTPases, which are crucial for chemical signaling within cells. GTPases are inactivated when bound to GDP and activated when bound to GTP. The FGD1 protein activates the GTPase Cdc42 by promoting the exchange of GDP for GTP. Once active, Cdc42 transmits signals essential for various developmental stages, particularly bone development. The FGD1 protein might also be involved in extracellular matrix remodeling, which influences cell migration and blood vessel remodeling.
FGD1 activates CDC42, a member of the Ras-like Rho- and Rac protein family, by exchanging bound GDP for free GTP. This process contributes to the regulation of the actin cytoskeleton and cell shape.
FGD1 is also known as AAS, FGDY, MRXS16, ZFYVE3.
