FFAR3
Title: The Enigma of FFAR3: A Novel Receptor with Diverse Biological Functions
Description:
Free fatty acid receptor 3 (FFAR3), also known as GPR41, is a G protein-coupled receptor (GPCR) that plays a crucial role in various physiological processes, including metabolism, inflammation, and pain. It is expressed in numerous tissues throughout the body, including the gastrointestinal tract, adipose tissue, immune cells, and the central nervous system. FFAR3 is activated by a range of ligands, primarily short-chain fatty acids (SCFAs), which are produced by the gut microbiome.
Associated Diseases:
Dysregulation of FFAR3 has been implicated in various diseases, including:
- Metabolic disorders: Obesity, insulin resistance, type 2 diabetes
- Gastrointestinal disorders: Inflammatory bowel disease (IBD), irritable bowel syndrome (IBS)
- Cardiovascular diseases: Atherosclerosis, hypertension
- Neurological disorders: Alzheimer's disease, Parkinson's disease
Did you Know ?
Research suggests that FFAR3 activation by SCFAs can improve insulin sensitivity by up to 50% in obese mice. This highlights the potential therapeutic benefits of targeting FFAR3 for metabolic disorders.
