FCHSD2
Description
The FCHSD2 (FCH and double SH3 domains 2) is a protein-coding gene located on chromosome 11.
FCH and double SH3 domains protein 2 is a protein that in humans is encoded by the FCHSD2 gene.
== Interactions == FCHSD2 has been shown to interact with MAGI1 and C2orf73.
FCHSD2 is an adapter protein that facilitates endocytosis via clathrin-coated pits. It plays a crucial role in internalizing cell surface receptors such as integrin ITGB1 and the transferrin receptor, and also promotes the endocytosis of EGFR in cancer cells, leading to the downregulation of EGFR signaling. FCHSD2 is recruited to clathrin-coated pits during a mid-to-late stage of assembly and is essential for the normal progression from U-shaped intermediate stage pits to terminal, omega-shaped pits. It binds to membranes rich in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate and, when bound, promotes actin polymerization through interaction with WAS and/or WASL, activating the Arp2/3 complex. Interestingly, FCHSD2 cannot promote actin polymerization in the absence of membranes.
FCHSD2 is also known as NWK, NWK1, SH3MD3.
