FCAMR
Description
The FCAMR (Fc alpha and mu receptor) is a protein-coding gene located on chromosome 1.
FCAMR acts as a receptor for the Fc fragments of IgA and IgM antibodies. It binds these antibodies with high affinity and triggers their internalization into cells. This process might play a role in the immune response to pathogens mediated by IgA and IgM.
FCAMR is also known as CD351, FCA/MR, FKSG87, Fcalpha/muR.
Associated Diseases
- hyper-IgM syndrome type 3
- hyper-IgM syndrome type 2
- hyper-IgM syndrome type 5
- autoimmune lymphoproliferative syndrome type 2B
- BENTA disease
- common variable immunodeficiency
- immunodeficiency, common variable, 14
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
- severe combined immunodeficiency due to CTPS1 deficiency
- immunodeficiency 105
- reticular dysgenesis
- immunodeficiency 18
- combined immunodeficiency with skin granulomas
- severe combined immunodeficiency due to CARD11 deficiency
- immunodeficiency 62
- severe combined immunodeficiency due to LAT deficiency
- lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome