FBXW9
Description
The FBXW9 (F-box and WD repeat domain containing 9) is a protein-coding gene located on chromosome 19.
FBXW9 plays a crucial role in protein degradation by acting as a substrate-recognition component within the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.
FBXW9 is also known as Fbw9, MEC-15.
Associated Diseases
- endometrial cancer
- urinary bladder cancer
- familial isolated congenital asplenia
- neuronal ceroid lipofuscinosis 1
- cancer
- familial papillary or follicular thyroid carcinoma
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
