FBXW7
Description
The FBXW7 gene plays a pivotal role in regulating cell growth and development by encoding a protein that acts as a tumor suppressor. This protein, known as F-box protein W7, is a component of a protein complex called the SCF complex. The SCF complex acts as a molecular machine, targeting specific proteins for degradation. FBXW7‘s role in protein degradation is critical for maintaining cellular homeostasis and preventing uncontrolled cell growth.
Associated Diseases
- Cancer (various types): FBXW7 mutations are frequently found in cancers like leukemia, lymphoma, breast cancer, and colorectal cancer.
- Neurodevelopmental disorders: Studies have linked FBXW7 mutations to certain neurodevelopmental disorders, including autism spectrum disorder and intellectual disability.
Did you know?
FBXW7 is one of the most frequently mutated genes in human cancers.
