FBXW10

Description

The FBXW10 (F-box and WD repeat domain containing 10) is a protein-coding gene located on chromosome 17.

FBXW10 is a protein encoded by the FBXW10 gene in humans. It belongs to the F-box protein family, characterized by a 40-amino acid F-box motif. FBXW10 plays a role in SCF complexes, which act as protein-ubiquitin ligases. These complexes are formed by SKP1, cullin, and F-box proteins, where FBXW10 interacts with SKP1 through its F box. It also interacts with ubiquitination targets through other protein interaction domains. Increased expression of FBXW10 has been linked to laminopathies and the degradation of chromatin-associated proteins like HP1 and ATR kinases.

FBXW10 acts as a substrate-recognition component within an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. This complex facilitates the ubiquitination and subsequent degradation of target proteins via the proteasome. Notably, FBXW10 overexpression leads to the degradation of CBX5 and CBX1.

FBXW10 is also known as Fbw10, HREP, SM25H2, SM2SH2.

Associated Diseases

WES Whole Exome Sequencing